Interstate '76 (Tested with GOG Version but should work with disc install as well.)
Install through Lutris's GOG game installer for Interstate 76.
Set game executable to i76.exe (Do NOT use the GOG Launcher).
Go to Wine configuration and set OS to Windows XP.
In Lutris Configure game, restrict number of cores under System options to 1 core.
Unselect Enable Feral GameMode (We don't want it to run.)
Game options..
prefix architecture -> Auto
Under Runner options
lutris-GE-Proton7-25-x86_64
disable everything under runner options except VKD3D, Esync, Fsync, & Create a sandbox for Wine folders.
Under System options
only have the following enabled:
Prefer system libraries
Restore resolution on game exit
Restrict number of cores used to 1
Xephyr fullscreen
Disable screen saver
open a terminal
go to the directory where the i76.exe executable is.
run the following command exactly as shown.*
printf 'xEBx22' | dd of=i76.exe bs=1 seek=626025 count=2 conv=notrunc
If you have the Nitro expansion installed also run the following from the path that nitro.exe is installed in.
printf 'xEBx22' | dd of=nitro.exe bs=1 seek=630921 count=2 conv=notrunc
Now try running the game in Lutris.
If it still doesn't work try the following from a terminal:
wget https://packages.microsoft. -O packages-microsoft-prod.deb
sudo dpkg -i packages-microsoft-prod.deb
rm packages-microsoft-prod.deb
sudo apt-get install -y dotnet-sdk-3.1
Also, you can go to the Wine configuration through Lutris for Interstate 76 and set i76.exe to run as Windows XP if you have problems getting it to run.
Other information:
Running ZorinOS 16
Kernel 5.15.0-75-generic
Lutris 0.5.11
*See https://www.winehq.org/ for details about modifying the exe for i76 and the nitro expansion. I haven't tried the Nitro expansion as of yet but feel confident it will work. This wouldn't have been possible without Anastasius Focht's, focht at gmx.net, post on winehq.com.